Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation

Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation

Abstract Severe malarial anemia (SMA; hemoglobin [Hb] <5.0 g/dL) is a leading global cause of morbidity and mortality among children residing in Plasmodium falciparum transmission regions. Exploration of molecular pathways through global gene expression profiling revealed that SMA was characteriz...

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Main Authors: Prakasha Kempaiah (Author), Karol Dokladny (Author), Zachary Karim (Author), Evans Raballah (Author), John M Ong'echa (Author), Pope L Moseley (Author), Douglas J Perkins (Author)
Format: Book
Published: BMC, 2016-08-01T00:00:00Z.
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