Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP‐1 and modulating gut microbiota

• Main Authors: Heng Wu (Author), Jing Wei (Author), Xiumiao Zhao (Author), Ying Liu (Author), Zhihang Chen (Author), Kehong Wei (Author), Jiachen Lu (Author), Wenjie Chen (Author), Meixiu Jiang (Author), Shengjie Li (Author), Tingtao Chen (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Considerable evidence suggests that insulin resistance is closely linked to Parkinson's disease (PD), leading to agents aiming at treating diabetes can be regarded as new neuroprotective strategies in PD, notably glucagon‐like peptide‐1 (GLP‐1). However, the extremely short half‐life o...