Toxoplasma gondii microneme protein MIC3 induces macrophage TNF-α production and Ly6C expression via TLR11/MyD88 pathway.

• Main Authors: Jingfan Qiu (Author), Yanci Xie (Author), Chenlu Shao (Author), Tianye Shao (Author), Min Qin (Author), Rong Zhang (Author), Xinjian Liu (Author), Zhipeng Xu (Author), Yong Wang (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toxoplasma gondii is the most successful parasite worldwide. It is of great interest to understand how T. gondii induce different immune responses in different hosts. In this study, we found that a peptide of T. gondii microneme protein MIC3 induced TNF-α production, NF-κB phosphorylation, iNOS tran...