Validation of Bone Marrow Derived Dendritic Cells as an Appropriate Model to Study Tumor-Mediated Suppression of DC Maturation through STAT3 Hyperactivation

• Main Authors: Aws Alshamsan (Author), Samar Hamdy (Author), Saswati Das Saswati Das (Author), Afsaneh Lavasanifar (Author), John Samuel (Author), Ayman O.S. El-Kadi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2010-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: Tumors can escape immune eradication by harnessing dendritic cell (DC) maturation. However, DC types used as in vitro models to study tumor-mediated immunosuppression possess fundamental variability that could influence research outcomes. Therefore, we assessed the behavior of two distinct...