Validation of Bone Marrow Derived Dendritic Cells as an Appropriate Model to Study Tumor-Mediated Suppression of DC Maturation through STAT3 Hyperactivation

• Egile Nagusiak: Aws Alshamsan (Egilea), Samar Hamdy (Egilea), Saswati Das Saswati Das (Egilea), Afsaneh Lavasanifar (Egilea), John Samuel (Egilea), Ayman O.S. El-Kadi (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2010-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

PURPOSE: Tumors can escape immune eradication by harnessing dendritic cell (DC) maturation. However, DC types used as in vitro models to study tumor-mediated immunosuppression possess fundamental variability that could influence research outcomes. Therefore, we assessed the behavior of two distinct...