Halogenase-Targeted Genome Mining Leads to the Discovery of (±) Pestalachlorides A1a, A2a, and Their Atropisomers

Halogenase-Targeted Genome Mining Leads to the Discovery of (±) Pestalachlorides A1a, A2a, and Their Atropisomers

Genome mining has become an important tool for discovering new natural products and identifying the cryptic biosynthesis gene clusters. Here, we utilized the flavin-dependent halogenase GedL as the probe in combination with characteristic halogen isotope patterns to mine new halogenated secondary me...

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Main Authors: Mengna Luo (Author), Mengyuan Wang (Author), Shanshan Chang (Author), Ning He (Author), Guangzhi Shan (Author), Yunying Xie (Author)
Format: Book
Published: MDPI AG, 2022-09-01T00:00:00Z.
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