Postnatal Maturation of the Glomerular Filtration Rate in Conventional Growing Piglets As Potential Juvenile Animal Model for Preclinical Pharmaceutical Research

• Main Authors: Elke Gasthuys (Author), Mathias Devreese (Author), Joske Millecam (Author), Stanislas Sys (Author), Katrien Vanderperren (Author), Joris Delanghe (Author), Johan Vande Walle (Author), Marjolein Heyndrickx (Author), Siska Croubels (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation. Over the years, pigs were presented as a potential animal model, since they display a high degree of anatomical and physiological similarities...