Icotinib derivatives as tyrosine kinase inhibitors with anti-esophageal squamous carcinoma activity

• Main Authors: Xiaojie Chen (Author), Long-Fei Mao (Author), Siqi Tian (Author), Xueli Tian (Author), Xueqiong Meng (Author), Mu-Kuo Wang (Author), Weifeng Xu (Author), Yue-Ming Li (Author), Kangdong Liu (Author), Zigang Dong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous report showed that a variety of icotinib derivatives bearing different 1,2,3-triazole moieties, which could be readily prepared via copper (I)-catalyzed cycloaddition (CuAAC) reaction between icotinib and different azides, exhibited interesting activity against different lung cancer cell li...