Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

• Main Authors: Rosalieke E. Wiegel (Author), Maud J. H. Karsten (Author), Igna F. Reijnders (Author), Lenie van Rossem (Author), Sten P. Willemsen (Author), Annemarie G. M. G. J. Mulders (Author), Anton H. J. Koning (Author), Eric A. P. Steegers (Author), A. H. Jan Danser (Author), Régine P. M. Steegers-Theunissen (Author)
• Format: Book
• Published: BMC, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Pregnancies with > 1 corpus luteum (CL) display a hyperdynamic circulation and an increased risk of small-for-gestational age deliveries. Among the factors released by the CL is prorenin, the inactive precursor of renin. Since the renin-angiotensin-aldosterone system (RAAS) is...