Topical paromomycin for New World cutaneous leishmaniasis.

• Main Authors: Néstor Sosa (Author), Juan Miguel Pascale (Author), Ana I Jiménez (Author), Jeanne A Norwood (Author), Mara Kreishman-Detrick (Author), Peter J Weina (Author), Kendra Lawrence (Author), William F McCarthy (Author), Ryan C Adams (Author), Charles Scott (Author), Janet Ransom (Author), Douglas Tang (Author), Max Grogl (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Paromomycin-based topical treatments were shown to be effective in curing cutaneous leishmaniasis (CL) lesions caused by Leishmania major in Tunisia. Cure rates of an index lesion were approximately 80%. As a follow on, we conducted a similar Phase 3 trial in Panama to...