LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model

• Main Authors: Ryoko Tsukahara (Author), Shinji Yamamoto (Author), Keisuke Yoshikawa (Author), Mari Gotoh (Author), Tamotsu Tsukahara (Author), Hiroyuki Neyama (Author), Satoshi Ishii (Author), Noriyuki Akahoshi (Author), Keisuke Yanagida (Author), Hayakazu Sumida (Author), Masatake Araki (Author), Kimi Araki (Author), Ken-ichi Yamamura (Author), Kimiko Murakami-Murofushi (Author), Hiroshi Ueda (Author)
• Format: Book
• Published: Elsevier, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lysophosphatidic acid (LPA) and LPA1 receptor signaling play a crucial role in the initiation of peripheral nerve injury-induced neuropathic pain through the alternation of pain-related genes/proteins expression and demyelination. However, LPA and its signaling in the brain are still poorly understo...