NRF2 Regulates Cystathionine Gamma-Lyase Expression and Activity in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus

• Main Authors: Mohammad Jamaluddin (Author), Aline Haas de Mello (Author), Nisha Tapryal (Author), Tapas K. Hazra (Author), Roberto P. Garofalo (Author), Antonella Casola (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2022-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Cystathionine-y-lyase (CSE) is a critical enzyme for hydrogen sulfide (H₂S) biosynthesis and plays a key role in respiratory syncytial virus (RSV) pathogenesis. The transcription factor NRF2 is the master regulator of cytoprotective and antioxidant gene expression, and is degr...