Mitigating ipatasertib‐induced glucose increase through dose and meal timing modifications

• Main Authors: Dhruvitkumar S. Sutaria (Author), Priya Agarwal (Author), Kuan‐Chieh Huang (Author), Dale R. Miles (Author), Jacob Rotmensch (Author), Heather Hinton (Author), Jorge Daniel Gallo (Author), Grozdana Rasuo (Author), Rucha S. Sane (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Ipatasertib, an AKT inhibitor, in combination with prednisone and abiraterone, is under evaluation for the treatment of metastatic castration‐resistant prostate cancer (mCRPC). Hyperglycemia is an on‐target effect of ipatasertib. An open‐label, single‐arm, single‐sequence, signal‐seeking st...