Synthetic anti-angiogenic genomic therapeutics for treatment of neovascular age-related macular degeneration

• Main Authors: Jing Wang (Author), Xiang Shi (Author), Qiyu Bo (Author), Hong Wang (Author), Fang Wei (Author), Jun Liu (Author), Hao Wang (Author), Liuwei Zhang (Author), Yan Qi (Author), Zhen Li (Author), Qixian Chen (Author), Xiaodong Sun (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In light of the intriguing potential of anti-angiogenic approach in suppressing choroidal neovascularization, we attempted to elaborate synthetic gene delivery systems encapsulating anti-angiogenic plasmid DNA as alternatives of clinical antibody-based therapeutics. Herein, block copolymer of cyclic...