Type-4 Phosphodiesterase (PDE4) Blockade Reduces NETosis in Cystic Fibrosis

• Main Authors: Licia Totani (Author), Concetta Amore (Author), Antonio Piccoli (Author), Giuseppe Dell'Elba (Author), Angelo Di Santo (Author), Roberto Plebani (Author), Romina Pecce (Author), Nicola Martelli (Author), Alice Rossi (Author), Serena Ranucci (Author), Ida De Fino (Author), Paolo Moretti (Author), Alessandra Bragonzi (Author), Mario Romano (Author), Virgilio Evangelista (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutrophilic inflammation is a key determinant of cystic fibrosis (CF) lung disease. Neutrophil-derived free DNA, released in the form of extracellular traps (NETs), significantly correlates with impaired lung function in patients with CF, underlying their pathogenetic role in CF lung disease. Thus,...