Early Transcriptional Signatures of the Immune Response to a Live Attenuated Tetravalent Dengue Vaccine Candidate in Non-human Primates.

• Main Authors: Fiona R Strouts (Author), Stephen J Popper (Author), Charalambos D Partidos (Author), Dan T Stinchcomb (Author), Jorge E Osorio (Author), David A Relman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of a vaccine against dengue faces unique challenges, including the complexity of the immune responses to the four antigenically distinct serotypes. Genome-wide transcriptional profiling provides insight into the pathways and molecular features that underlie responses to immune system...