Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights

• Main Authors: Nicholas Heeley (Author), Peter Kirwan (Author), Tamana Darwish (Author), Marion Arnaud (Author), Mark L. Evans (Author), Florian T. Merkle (Author), Frank Reimann (Author), Fiona M. Gribble (Author), Clemence Blouet (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which hypothalamic neural circuits controlling behavior and metabolism sense pr...