IL-37 Suppresses MyD88-mediated Inflammatory Responses in Human Aortic Valve Interstitial Cells

• Main Authors: Qiong Zhan (Author), Qingchun Zeng (Author), Rui Song (Author), Yufeng Zhai (Author), Dingli Xu (Author), David A. Fullerton (Author), Charles A. Dinarello (Author), Xianzhong Meng (Author)
• Format: Book
• Published: BMC, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Calcific aortic valve disease (CAVD) is common among the elderly, and aortic valve interstitial cells (AVICs) exhibit unique inflammatory and osteogenic responses to proinflammatory stimulation, which plays an important role in valvular fibrosis and calcification. Thus, suppression of AVIC...