The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells

• Автори: Abel M. Mengeste (Автор), Jenny Lund (Автор), Parmeshwar Katare (Автор), Roya Ghobadi (Автор), Hege G. Bakke (Автор), Per Kristian Lunde (Автор), Lars Eide (Автор), Gavin O' Mahony (Автор), Sven Göpel (Автор), Xiao-Rong Peng (Автор), Eili Tranheim Kase (Автор), G. Hege Thoresen (Автор), Arild C. Rustan (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2021-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background and objective: A number of studies have highlighted muscle-specific mechanisms of thermogenesis involving futile cycling of Ca2+ driven by sarco (endo)plasmic reticulum Ca2+-ATPase (SERCA) and generating heat from ATP hydrolysis to be a promising strategy to counteract obesity and metabol...