The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells

• Main Authors: Abel M. Mengeste (Author), Jenny Lund (Author), Parmeshwar Katare (Author), Roya Ghobadi (Author), Hege G. Bakke (Author), Per Kristian Lunde (Author), Lars Eide (Author), Gavin O' Mahony (Author), Sven Göpel (Author), Xiao-Rong Peng (Author), Eili Tranheim Kase (Author), G. Hege Thoresen (Author), Arild C. Rustan (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and objective: A number of studies have highlighted muscle-specific mechanisms of thermogenesis involving futile cycling of Ca2+ driven by sarco (endo)plasmic reticulum Ca2+-ATPase (SERCA) and generating heat from ATP hydrolysis to be a promising strategy to counteract obesity and metabol...