Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms

• Автори: Takeshi Sakata (Автор), Naohiko Anzai (Автор), Toru Kimura (Автор), Daisaku Miura (Автор), Toshiyuki Fukutomi (Автор), Michio Takeda (Автор), Hiroyuki Sakurai (Автор), Hitoshi Endou (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2010-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibited reduced uptake of both [ 3H]histamine and [3H]...