Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms

• Egile Nagusiak: Takeshi Sakata (Egilea), Naohiko Anzai (Egilea), Toru Kimura (Egilea), Daisaku Miura (Egilea), Toshiyuki Fukutomi (Egilea), Michio Takeda (Egilea), Hiroyuki Sakurai (Egilea), Hitoshi Endou (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2010-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibited reduced uptake of both [ 3H]histamine and [3H]...