Non-Toxigenic <i>Clostridioides difficile</i> Strain E4 (NTCD-E4) Prevents Establishment of Primary <i>C. difficile</i> Infection by Epidemic PCR Ribotype 027 in an In Vitro Human Gut Model

• Main Authors: Perezimor Etifa (Author), César Rodríguez (Author), Céline Harmanus (Author), Ingrid M. J. G. Sanders (Author), Igor A. Sidorov (Author), Olufunmilayo A. Mohammed (Author), Emily Savage (Author), Andrew R. Timms (Author), Jane Freeman (Author), Wiep Klaas Smits (Author), Mark H. Wilcox (Author), Simon D. Baines (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Clostridioides difficile</i> infection (CDI) remains a significant healthcare burden. Non-toxigenic <i>C. difficile</i> (NTCD) strains have shown a benefit in preventing porcine enteritis and in human recurrent CDI. In this study, we evaluated the efficacy of metronidazole...