Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention

• Main Authors: Kerstin Benz (Author), Julia Schlote (Author), Christoph Daniel (Author), Christoph Kopp (Author), Anke Dahlmann (Author), Agnes Schröder (Author), Nada Cordasic (Author), Bernd Klanke (Author), Karl Hilgers (Author), Jens Titze (Author), Kerstin Amann (Author)
• Format: Book
• Published: Karger Publishers, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: One potential pathomechanism how low nephron number leads to hypertension in later life is altered salt handling. We therefore evaluated changes in electrolyte and water content in wildtype (wt) and GDNF+/- mice with a 30% reduction of nephron number. Methods: 32 GDNF+/- and 36 wt m...