Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes

• Главные авторы: Liora S. Katz (Автор), Gabriel Brill (Автор), Peng Wang (Автор), Luca Lambertini (Автор), Pili Zhang (Автор), Jonathan M. Haldeman (Автор), Hongtao Liu (Автор), Christopher B. Newgard (Автор), Andrew F. Stewart (Автор), Adolfo Garcia-Ocaña (Автор), Donald K. Scott (Автор)
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• Опубликовано: Elsevier, 2024-01-01T00:00:00Z.
• Предметы: article
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Objective: All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding of how β-cells proliferate. Glucose is a natural β-cell mitogen that mediates its effects in part through the gl...