Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes

• Main Authors: Liora S. Katz (Author), Gabriel Brill (Author), Peng Wang (Author), Luca Lambertini (Author), Pili Zhang (Author), Jonathan M. Haldeman (Author), Hongtao Liu (Author), Christopher B. Newgard (Author), Andrew F. Stewart (Author), Adolfo Garcia-Ocaña (Author), Donald K. Scott (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding of how β-cells proliferate. Glucose is a natural β-cell mitogen that mediates its effects in part through the gl...