Process validation and preclinical development of a new PET cerebral blood flow tracer [11C]MMP for initial clinical trials

• मुख्य लेखकों: Jun Toyohara (लेखक), Tetsuro Tago (लेखक), Muneyuki Sakata (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: SpringerOpen, 2024-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) is commonly used for diagnosis of dementia because brain glucose metabolism reflects neuronal activity. However, as [18F]FDG is an analogue of glucose, accumulation of tracer in the brain is affected by plasma glucose levels. In contrast...