Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates

• 主要な著者: Qiong Xiao (著者), Minwan Hu (著者), Si Chen (著者), Yifan Tang (著者), Zeyu Shi (著者), Jing Jin (著者), Jinping Hu (著者), Ping Xie (著者), Dali Yin (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2020-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

FTY720 and IMMH002, prodrugs for sphingosine-1-phosphate receptor 1 (S1P1) agonists, show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats. In this study, FTY720 or IMMH002 analogues (21-24) were designed and synthesized with modified head pieces to improve th...