Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates

• Main Authors: Qiong Xiao (Author), Minwan Hu (Author), Si Chen (Author), Yifan Tang (Author), Zeyu Shi (Author), Jing Jin (Author), Jinping Hu (Author), Ping Xie (Author), Dali Yin (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

FTY720 and IMMH002, prodrugs for sphingosine-1-phosphate receptor 1 (S1P1) agonists, show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats. In this study, FTY720 or IMMH002 analogues (21-24) were designed and synthesized with modified head pieces to improve th...