Impact of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of lenvatinib in patients with hepatocellular carcinoma

• Main Authors: Hironao Okubo (Author), Hitoshi Ando (Author), Kei Ishizuka (Author), Jun-ichi Morishige (Author), Kenichi Ikejima (Author), Shuichiro Shiina (Author), Akihito Nagahara (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This prospective study examined the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of lenvatinib, a substrate of ATP-binding transporters, in a cohort of 48 Japanese patients with hepatocellular carcinoma (HCC). Pharmacokinetic studies were performed at the...