Induction of whole-body gene deletion via R26-regulated tamoxifen-inducible Cre recombinase activity

• প্রধান লেখক: Rahul Kumar (লেখক), Yun Mao (লেখক), Sonika Patial (লেখক), Yogesh Saini (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Germline deletion of certain genes causes embryonic lethality, therefore, understanding the effect of deletion of such genes on mammalian pathophysiology remains challenging. Tamoxifen (TAM)-inducible Cre recombinase is widely used for tissue-specific and temporal induction of gene deletion in mice....