1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1

• Main Authors: Kazuhiko Seya (Author), Ken-Ichi Furukawa (Author), Mari Chiyoya (Author), Zaiqiang Yu (Author), Haruhisa Kikuchi (Author), Kazuyuki Daitoku (Author), Shigeru Motomura (Author), Manabu Murakami (Author), Yoshiteru Oshima (Author), Ikuo Fukuda (Author)
• Format: Knjiga
• Izdano: Elsevier, 2016-05-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

An abnormally high serum phosphate level induces calcific aortic stenosis (CAS), which is characterized by ectopic valve calcification and stenosis of the orifice area. Inhibition of ectopic calcification is a critical function of any internal medical therapy for CAS disease. The aim of the present...