1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1

1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1

An abnormally high serum phosphate level induces calcific aortic stenosis (CAS), which is characterized by ectopic valve calcification and stenosis of the orifice area. Inhibition of ectopic calcification is a critical function of any internal medical therapy for CAS disease. The aim of the present...

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Main Authors: Kazuhiko Seya (Author), Ken-Ichi Furukawa (Author), Mari Chiyoya (Author), Zaiqiang Yu (Author), Haruhisa Kikuchi (Author), Kazuyuki Daitoku (Author), Shigeru Motomura (Author), Manabu Murakami (Author), Yoshiteru Oshima (Author), Ikuo Fukuda (Author)
Format: Book
Published: Elsevier, 2016-05-01T00:00:00Z.
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