Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model

• Main Authors: Chandra Mohan Reddy Muthumula (Author), Sangeeta Khare (Author), Rajan Jog (Author), Bhagya Wickramaratne (Author), Angela Lee (Author), Sushanta Chakder (Author), Diane J. Burgess (Author), Kuppan Gokulan (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zileuton is a leukotriene inhibitor used to treat asthma. As a BCS class II drug it exhibits challenges with solubility which likely impact its absorption. As patient gender significantly impacts the pharmacokinetics of many drugs, this study aimed to investigate potential gender-based pharmacokinet...