3D-QSAR and Docking Studies on Pyrimidine Derivatives of Second-Generation ALK Inhibitors

Anaplastic lymphoma kinase (ALK) is a promising target for the treatment of non-small cell lung cancer. Under crizotinib treatment, drug resistance and progressive disease appeared after the point mutations arising in the kinase domain of ALK. Second-generation ALK inhibitors can solve the deficienc...

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Main Authors: Gang-Long Jiang (Author), Lian-Hua Song (Author), Yong-Fu Qiu (Author), Yu Liu (Author)
Format: Book
Published: Georg Thieme Verlag KG, 2022-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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