Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

• Asıl Yazarlar: Arnold Donkor Forkuo (Yazar), Charles Ansah (Yazar), David Pearson (Yazar), Werner Gertsch (Yazar), Amanda Cirello (Yazar), Adam Amaral (Yazar), Jaimie Spear (Yazar), Colin W. Wright (Yazar), Caroline Rynn (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: BMC, 2017-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Background This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in mal...