Strategies for Developing Sensitive and Automated LC-MS/MS Assays of a Pharmaceutical Compound and Its Metabolite from Whole Blood Matrix

• Main Authors: Raymond N. Xu (Author), Jill Polzin (Author), Michelle Kranz (Author), Phillip Vaca (Author), Maria Metchkarova (Author), Matthew J. Rieser (Author), Tawakol A. El-Shourbagy (Author)
• Format: Book
• Published: MDPI AG, 2010-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

When compared with biological samples in other matrices (plasma, urine, etc.) that are typically seen in bioanalytical applications, whole blood samples present unique challenges in method development, because of the viscous nature of blood and complexity of its constituents. In this article, we hav...