Characterization of a Novel CYP2C9 Mutation (1009C>A) Detected in a Warfarin-Sensitive Patient

• Autores principales: Shun-Bin Luo (Autor), Chuan-Bao Li (Autor), Da-Peng Dai (Autor), Shuang-Hu Wang (Autor), Zhen-He Wang (Autor), Pei-Wu Geng (Autor), Jie Cai (Autor), Zhe-Li Jiang (Autor), Cheng-Wei Pu (Autor), Ke Shang (Autor), Xin-Min Yuan (Autor), Ya-Po Cao (Autor), Guo-Xin Hu (Autor), Jian-Ping Cai (Autor)
• Formato: Libro
• Publicado: Elsevier, 2014-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract.: Warfarin is the most frequently prescribed anticoagulant for the long-term treatment in the clinic. Recent studies have shown that polymorphic alleles within the CYP2C9, VKORC1, and CYP4F2 genes are related to the warfarin dosage requirement. In this study, a novel nonsynonymous mutation...