Characterization of a Novel CYP2C9 Mutation (1009C>A) Detected in a Warfarin-Sensitive Patient

• Main Authors: Shun-Bin Luo (Author), Chuan-Bao Li (Author), Da-Peng Dai (Author), Shuang-Hu Wang (Author), Zhen-He Wang (Author), Pei-Wu Geng (Author), Jie Cai (Author), Zhe-Li Jiang (Author), Cheng-Wei Pu (Author), Ke Shang (Author), Xin-Min Yuan (Author), Ya-Po Cao (Author), Guo-Xin Hu (Author), Jian-Ping Cai (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Warfarin is the most frequently prescribed anticoagulant for the long-term treatment in the clinic. Recent studies have shown that polymorphic alleles within the CYP2C9, VKORC1, and CYP4F2 genes are related to the warfarin dosage requirement. In this study, a novel nonsynonymous mutation...