Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy

• Main Authors: Zhanbo Yang (Author), Bizhu Chu (Author), Yao Tu (Author), Lulu Li (Author), Dawei Chen (Author), Shouhui Huang (Author), Wenjun Huang (Author), Weiwen Fan (Author), Qinyuan Li (Author), Cunlong Zhang (Author), Zigao Yuan (Author), Jumin Huang (Author), Elaine Lai-Han Leung (Author), Yuyang Jiang (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer is the second most prevalent and deadly cancer worldwide. The emergence of immune checkpoint therapy has provided a revolutionary strategy for the treatment of solid tumors. However, less than 5 % of colorectal cancer patients respond to immune checkpoint therapy. Thus, it is of gr...