The Use of the QbD Approach to Optimize the Co-Loading of Simvastatin and Doxorubicin in Liposomes for a Synergistic Anticancer Effect

• Main Authors: Cristina-Ioana Barbalata (Author), Alina Silvia Porfire (Author), Tibor Casian (Author), Dana Muntean (Author), Iulia Rus (Author), Mihaela Tertis (Author), Cecilia Cristea (Author), Anca Pop (Author), Julien Cherfan (Author), Felicia Loghin (Author), Ioan Tomuta (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aimed to optimize a liposomal formulation co-encapsulating simvastatin (SIM) and doxorubicin (DOX) that has future perspectives in anticancer therapy. The optimization process was performed by implementing the Quality by Design concept and by considering the results of a previous s...