Phenotyping of circulating extracellular vesicles (EVs) in obesity identifies large EVs as functional conveyors of Macrophage Migration Inhibitory Factor

• Main Authors: Jérémy Amosse (Author), Maëva Durcin (Author), Marine Malloci (Author), Luisa Vergori (Author), Audrey Fleury (Author), Frédéric Gagnadoux (Author), Séverine Dubois (Author), Gilles Simard (Author), Jérôme Boursier (Author), Olivier Hue (Author), M. Carmen Martinez (Author), Ramaroson Andriantsitohaina (Author), Soazig Le Lay (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity-associated metabolic dysfunctions are linked to dysregulated production of adipokines. Accumulating evidence suggests a role for fat-derived extracellular vesicles (EVs) in obesity-metabolic disturbances. Since EVs convey numerous proteins we aimed to evaluate their contribution i...