Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling

• Main Authors: Xinyue Lv (Author), Peipei Ding (Author), Luying Li (Author), Ling Li (Author), Danlei Zhou (Author), Xiaochao Wang (Author), Jianfeng Chen (Author), Wei Zhang (Author), Qi Wang (Author), Tian Liao (Author), Wenyu Wen (Author), Dawang Zhou (Author), Qing-Hai Ji (Author), Xianghuo He (Author), Qun-Ying Lei (Author), Weiguo Hu (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sufficient evidence has linked many different types of cancers and T2D through shared risk factors; however, the underlying mechanisms are not fully understood. α-Hydroxybutyrate (α-HB), a byproduct metabolite increased in diabetes and cancer, including colorectal cancer (CRC), triggers lactate dehy...