Prediction of long-term polysorbate degradation according to short-term degradation kinetics

• Hauptverfasser: Sisi Zhang (Verfasst von), Caterina Riccardi (Verfasst von), Dane Carlson (Verfasst von), Douglas Kamen (Verfasst von), Kenneth S. Graham (Verfasst von), Mohammed Shameem (Verfasst von), Hanne Bak (Verfasst von), Hui Xiao (Verfasst von), Ning Li (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

ABSTRACTPolysorbates (PSs) are a class of surfactants commonly used in the formulation of protein therapeutic agents to provide protection against denaturation and aggregation. When the PS in these drug formulations degrades, loss of stabilization of the protein therapeutic and formulation may occur...