Prediction of long-term polysorbate degradation according to short-term degradation kinetics

• Main Authors: Sisi Zhang (Author), Caterina Riccardi (Author), Dane Carlson (Author), Douglas Kamen (Author), Kenneth S. Graham (Author), Mohammed Shameem (Author), Hanne Bak (Author), Hui Xiao (Author), Ning Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTPolysorbates (PSs) are a class of surfactants commonly used in the formulation of protein therapeutic agents to provide protection against denaturation and aggregation. When the PS in these drug formulations degrades, loss of stabilization of the protein therapeutic and formulation may occur...