Tricyclic Fused Lactams by Mukaiyama Cyclisation of Phthalimides and Evaluation of their Biological Activity
We report that phthalimides may be cyclized using a Mukaiyama-type aldol coupling to give variously substituted fused lactam (1,2,3,9b-tetrahydro-5<i>H</i>-pyrrolo[2,1-<i>a</i>]isoindol-5-one) systems. This novel process shows a high level of regioselectivity for <i>o&l...
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MDPI AG,
2022-12-01T00:00:00Z.
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