Tricyclic Fused Lactams by Mukaiyama Cyclisation of Phthalimides and Evaluation of their Biological Activity

• Main Authors: Lewis T. Ibbotson (Author), Kirsten E. Christensen (Author), Miroslav Genov (Author), Alexander Pretsch (Author), Dagmar Pretsch (Author), Mark G. Moloney (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report that phthalimides may be cyclized using a Mukaiyama-type aldol coupling to give variously substituted fused lactam (1,2,3,9b-tetrahydro-5<i>H</i>-pyrrolo[2,1-<i>a</i>]isoindol-5-one) systems. This novel process shows a high level of regioselectivity for <i>o&l...