Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening

• Glavni autori: Danfeng Shi (Autor), Qianqian Pang (Autor), Qianyu Qin (Autor), Xinsheng Yao (Autor), Xiaojun Yao (Autor), Yang Yu (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Poly (ADP-ribose) polymerase 1 (PARP-1) is a critical enzyme involved in DNA damage repair and recombination, and shows great potential for drug development in the treatment of cancers with defective DNA repair. The anti-tumor activities of PARP-1 inhibitors are regulated by both inhibition activiti...