Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening

• 主要な著者: Danfeng Shi (著者), Qianqian Pang (著者), Qianyu Qin (著者), Xinsheng Yao (著者), Xiaojun Yao (著者), Yang Yu (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Poly (ADP-ribose) polymerase 1 (PARP-1) is a critical enzyme involved in DNA damage repair and recombination, and shows great potential for drug development in the treatment of cancers with defective DNA repair. The anti-tumor activities of PARP-1 inhibitors are regulated by both inhibition activiti...