Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with XenF-mediated sigmatropic rearrangement as a prerequisite

• Main Authors: Zhiguo Liu (Author), Wei Li (Author), Peng Zhang (Author), Jie Fan (Author), Fangbo Zhang (Author), Caixia Wang (Author), Shuming Li (Author), Yi Sun (Author), Shilin Chen (Author), Wenbing Yin (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tyrosine-decahydrofluorene derivatives feature a fused [6.5.6] tricarbocyclic core and a 13-membered para-cyclophane ether. Herein, we identified new xenoacremones A, B, and C (1−3) from the fungal strain Xenoacremonium sinensis ML-31 and elucidated their biosynthetic pathway using gene deletion in...