Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options

• Hoofdauteurs: Margaretha A. Skowron (Auteur), Mara Kotthoff (Auteur), Felix Bremmer (Auteur), Katja Ruhnke (Auteur), Fatma Parmaksiz (Auteur), Annika Richter (Auteur), Stefan Küffer (Auteur), Kirsten Reuter-Jessen (Auteur), Stella Pauls (Auteur), Anja Stefanski (Auteur), Philipp Ströbel (Auteur), Kai Stühler (Auteur), Daniel Nettersheim (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2023-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background Being the standard-of-care for four decades, cisplatin-based chemotherapy is highly efficient in treating germ cell tumors (GCT). However, often refractory patients present with a remaining (resistant) yolk-sac tumor (YST(-R)) component, resulting in poor prognosis due to lack of...