Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options

• Main Authors: Margaretha A. Skowron (Author), Mara Kotthoff (Author), Felix Bremmer (Author), Katja Ruhnke (Author), Fatma Parmaksiz (Author), Annika Richter (Author), Stefan Küffer (Author), Kirsten Reuter-Jessen (Author), Stella Pauls (Author), Anja Stefanski (Author), Philipp Ströbel (Author), Kai Stühler (Author), Daniel Nettersheim (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Being the standard-of-care for four decades, cisplatin-based chemotherapy is highly efficient in treating germ cell tumors (GCT). However, often refractory patients present with a remaining (resistant) yolk-sac tumor (YST(-R)) component, resulting in poor prognosis due to lack of...