Application of a UPLC-MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma

• Main Authors: Hui Liu (Author), Pan-Pan Wu (Author), Ming-Jing Yang (Author), Lei Men (Author), Hong-Li Lin (Author), Yun-Li Zhao (Author), Xing Tang (Author), Zhi-Guo Yu (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TM-2 known as a potential antitumor drug is a novel semi-synthetic taxane derivative. As drug-protein interactions contribute to insights into pharmacokinetic and pharmacodynamic properties, we elucidated the binding of TM-2 to plasma protein. In this study, a simple, rapid and reliable method was d...