A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming

• Main Authors: Yang Zhou (Author), Sahar Alimohamadi (Author), Li Wang (Author), Ziqing Liu (Author), Joseph B. Wall (Author), Chaoying Yin (Author), Jiandong Liu (Author), Li Qian (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Direct reprogramming of cardiac fibroblasts (CFs) to induced cardiomyocytes (iCMs) is a newly emerged promising approach for cardiac regeneration, disease modeling, and drug discovery. However, its potential has been drastically limited due to the low reprogramming efficiency and largely unknown und...