Mechanistic Insights Into Co-Administration of Allosteric and Orthosteric Drugs to Overcome Drug-Resistance in T315I BCR-ABL1

• Main Authors: Hao Zhang (Author), Mingsheng Zhu (Author), Mingzi Li (Author), Duan Ni (Author), Yuanhao Wang (Author), Liping Deng (Author), Kui Du (Author), Shaoyong Lu (Author), Hui Shi (Author), Chen Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, driven by the BCR-ABL1 fusion oncoprotein. The discovery of orthosteric BCR-ABL1 tyrosine kinase inhibitors (TKIs) targeting its active ATP-binding pocket, such as first-generation Imatinib and second-generation Nilotinib (NIL), has pr...