Cover Image

PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC

High expression of programmed death-ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) cells usually inhibits the proliferation and functions of T cells, leading to immune suppression in tumor microenvironment. However, very little has been described regarding the mechanism of PD-L1 overexpression i...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiao Wang (Author), Chao Liang (Author), Xin Yao (Author), Ruo-Han Yang (Author), Zhan-Sheng Zhang (Author), Fan-Ye Liu (Author), Wen-Qi Li (Author), Shu-Hua Pei (Author), Jing Ma (Author), Song-Qiang Xie (Author), Dong Fang (Author)
Format:	Book
Published:	Frontiers Media S.A., 2020-11-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Corrigendum: PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC
by: Xiao Wang, et al.
Published: (2021)

KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2
by: Chaofan Peng, et al.
Published: (2024)

TKI or TKI combined with PD-1 inhibitors as second-line treatment for HCC patients after sorafenib failure
by: Jin Lei, et al.
Published: (2022)

Elevated Serum Uric Acid is Associated With Poor Survival in Advanced HCC Patients and Febuxostat Improves Prognosis in HCC Rats
by: Le Wu, et al.
Published: (2021)

Berberine Targets PKM2 to Activate the t-PA-Induced Fibrinolytic System and Improves Thrombosis
by: Zeqi Sun, et al.
Published: (2024)

Desquamated Epithelial Cells of Unstimulated Human Whole Saliva Express Both EGF Transcript and Protein
by: Alexandra Aidoukovitch, et al.
Published: (2022)

Tenofovir is superior to entecavir in reducing HCC for patients with HBV-related compensated cirrhosis at high HCC risk scores
by: Yan Huang, et al.
Published: (2022)

Research Progress on the Mechanism of Histone Deacetylases in Ferroptosis of Glioma
by: Meng Ma, et al.
Published: (2024)

2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells
by: Wuguo Li, et al.
Published: (2019)

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.
by: Letícia Anderson, et al.
Published: (2017)

Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation
by: Mei-Yu Shen, et al.
Published: (2023)

EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes
by: Xinyu Liu, et al.
Published: (2022)

Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2
by: Zhaoxia Zhang, et al.
Published: (2016)

SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence
by: Xuejiao Chen, et al.
Published: (2024)

Shikonin contributes to intestinal epithelial cell differentiation through PKM2/NRF2-mediated Polyol pathway
by: Ling Huang, et al.
Published: (2021)

Histone H3 methylation orchestrates transcriptional program in mouse spermatogenic cell line
by: Xiao-fei WANG, et al.
Published: (2020)

Performance of HCC diagnosis in the KLCA-NCC guidelines: a closer look at MRI contrast agents and HCC imaging hallmarks
by: Ji Hye Min, et al.
Published: (2024)

Combined Treatment of Activin A and Heparin Binding-EGF (HB-EGF) Enhances In Vitro Production of Bovine Embryos
by: Se-woong Kim, et al.
Published: (2014)

PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer
by: Akira Koshino, et al.
Published: (2022)

Astragalus polysaccharide (APS) attenuated PD-L1-mediated immunosuppression via the miR-133a-3p/MSN axis in HCC
by: Lihua He, et al.
Published: (2022)

The potential of mRNA vaccine in HCC treatment
by: Rui Han
Published: (2023)

Mechanism of sorafenib resistance associated with ferroptosis in HCC
by: Lingling Guo, et al.
Published: (2023)

PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
by: Yinjiaozhi Li, et al.
Published: (2023)

Sarcosine May Induce EGF Production or Inhibit the Decline in EGF Concentrations in Patients with Chronic Schizophrenia (Results of the PULSAR Study)
by: Agnieszka Pawlak, et al.
Published: (2023)

Shengqing Jiangzhuo decoction regulates the immunosuppressive microenvironment via the STAT3 signaling pathway for the treatment of malignant ascites in HCC
by: Gaofei Feng, et al.
Published: (2024)

Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo
by: Melanie J. Mittenbühler, et al.
Published: (2020)

TSC2 Mutations Were Associated with the Early Recurrence of Patients with HCC Underwent Hepatectomy
by: Song K, et al.
Published: (2021)

Correction: PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
by: Yinjiaozhi Li, et al.
Published: (2024)

Mechanism of action of egfs in peri-implant physiology
by: Luciano Bonatelli Bispo, et al.
Published: (2018)

CHK2 Promotes Metabolic Stress-Induced Autophagy through ULK1 Phosphorylation
by: Ran Guo, et al.
Published: (2022)

Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites
by: Lingli Mu, et al.
Published: (2016)

The Contribution of Histone Crotonylation to Tissue Health and Disease: Focus on Kidney Health
by: Julio M. Martinez-Moreno, et al.
Published: (2020)

Extracellular vesicles in the HCC microenvironment: Implications for therapy and biomarkers
by: Le Cheng, et al.
Published: (2024)

Modulation of the Cytotoxic Properties of Pd(II) Complexes Based on Functionalized Carboxamides Featuring Labile Phosphoryl Coordination Sites
by: Diana V. Aleksanyan, et al.
Published: (2023)

PROGRAM KEMITRAAN MASYARAKAT (PKM) PENGRAJIN DAUR ULANG SAMPAH
by: Devi Endah Saraswati, et al.
Published: (2018)

Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis
by: Naheed eFatima, et al.
Published: (2015)

LDHA-induced histone lactylation mediates the development of osteoarthritis through regulating the transcription activity of TPI1 gene
by: Junfeng Xia, et al.
Published: (2024)

Donafenib in Chinese patients with advanced hepatocellular carcinoma (HCC): Really a new standard of care, or should we change paradigm for drug development in HCC?
by: Francesca Negri, et al.
Published: (2021)

Zinc binding groups for histone deacetylase inhibitors
by: Lei Zhang, et al.
Published: (2018)

EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development.
by: Zhe Cheng, et al.
Published: (2017)