PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC

• Main Authors: Xiao Wang (Author), Chao Liang (Author), Xin Yao (Author), Ruo-Han Yang (Author), Zhan-Sheng Zhang (Author), Fan-Ye Liu (Author), Wen-Qi Li (Author), Shu-Hua Pei (Author), Jing Ma (Author), Song-Qiang Xie (Author), Dong Fang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High expression of programmed death-ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) cells usually inhibits the proliferation and functions of T cells, leading to immune suppression in tumor microenvironment. However, very little has been described regarding the mechanism of PD-L1 overexpression i...