PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC

• Päätekijät: Xiao Wang (Tekijä), Chao Liang (Tekijä), Xin Yao (Tekijä), Ruo-Han Yang (Tekijä), Zhan-Sheng Zhang (Tekijä), Fan-Ye Liu (Tekijä), Wen-Qi Li (Tekijä), Shu-Hua Pei (Tekijä), Jing Ma (Tekijä), Song-Qiang Xie (Tekijä), Dong Fang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

High expression of programmed death-ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) cells usually inhibits the proliferation and functions of T cells, leading to immune suppression in tumor microenvironment. However, very little has been described regarding the mechanism of PD-L1 overexpression i...