Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis

• Main Authors: Zhaojuan Guo (Author), Pin Li (Author), Chunguo Wang (Author), Qianjun Kang (Author), Can Tu (Author), Bingqian Jiang (Author), Jingxuan Zhang (Author), Weiling Wang (Author), Ting Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Backgrounds: Psoraleae Fructus (PF)-induced hepatotoxicity has been reported in clinical and animal experiments. However, the hepatotoxic constituents and mechanisms underlying PF-induced toxicity have remained unclear. Therefore, this study explored the potentially toxic PF components and revealed...