Synthesis and Evaluation of Some New 4<i>H</i>-Pyran Derivatives as Antioxidant, Antibacterial and Anti-HCT-116 Cells of CRC, with Molecular Docking, Antiproliferative, Apoptotic and ADME Investigations

Synthesis and Evaluation of Some New 4<i>H</i>-Pyran Derivatives as Antioxidant, Antibacterial and Anti-HCT-116 Cells of CRC, with Molecular Docking, Antiproliferative, Apoptotic and ADME Investigations

Colorectal cancer oncogenesis is linked to dysbiosis, oxidative stress and overexpression of CDK2. The 4<i>H</i>-pyran scaffold is considered an antitumoral, antibacterial and antioxidant lead as well as a CDK2 inhibitor. Herein, certain 4<i>H</i>-pyran derivatives were evalu...

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Main Authors: Nahed N. E. El-Sayed (Author), Magdi E. A. Zaki (Author), Sami A. Al-Hussain (Author), Abir Ben Bacha (Author), Malika Berredjem (Author), Vijay H. Masand (Author), Zainab M. Almarhoon (Author), Hanaa S. Omar (Author)
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Published: MDPI AG, 2022-07-01T00:00:00Z.
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