Synthesis and Evaluation of Some New 4<i>H</i>-Pyran Derivatives as Antioxidant, Antibacterial and Anti-HCT-116 Cells of CRC, with Molecular Docking, Antiproliferative, Apoptotic and ADME Investigations

• Egile Nagusiak: Nahed N. E. El-Sayed (Egilea), Magdi E. A. Zaki (Egilea), Sami A. Al-Hussain (Egilea), Abir Ben Bacha (Egilea), Malika Berredjem (Egilea), Vijay H. Masand (Egilea), Zainab M. Almarhoon (Egilea), Hanaa S. Omar (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Colorectal cancer oncogenesis is linked to dysbiosis, oxidative stress and overexpression of CDK2. The 4<i>H</i>-pyran scaffold is considered an antitumoral, antibacterial and antioxidant lead as well as a CDK2 inhibitor. Herein, certain 4<i>H</i>-pyran derivatives were evalu...