Prediction of Drug-Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation

• Main Authors: Beihong Ji (Author), Shuhan Liu (Author), Ying Xue (Author), Xibing He (Author), Viet Hoang Man (Author), Xiang-Qun Xie (Author), Junmei Wang (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Researchers have long been interested in the potential drug-drug interactions (DDIs) between opioids and benzodiazepines. However, much remains unknown concerning the interactions between these two drug classes. The objective of this work is to study the mechanism underlying the...